Alkaloids of fascaplysin are promising chemotherapeutic agents for the treatment of glioblastoma: Review

Irina Lyakhova; Mariia Piatkova; Valeriia Gulaia; Aleksandr Romanishin; Mikhail Shmelev; Andrey Bryukhovetskiy; Aruna Sharma; Hari Shanker Sharma; Rodion Khotimchenko; Igor Bryukhovetskiy

doi:10.1016/bs.irn.2020.03.010

Alkaloids of fascaplysin are promising chemotherapeutic agents for the treatment of glioblastoma: Review

Int Rev Neurobiol. 2020:151:299-324. doi: 10.1016/bs.irn.2020.03.010. Epub 2020 May 13.

Affiliations

¹ Department of Fundamental Medicine, School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia.
² Laboratory of Biomedical Cell Technologies, Department of Medical Biology and Biotechnology, School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia.
³ NeuroVita Clinic of Interventional and Restorative Neurology and Therapy, Moscow, Russia.
⁴ International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, University Hospital, Uppsala University, S-75185 Uppsala, Sweden.
⁵ Department of Fundamental Medicine, School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia; Laboratory of Pharmacology, National Scientific Center of Marine Biology, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia.
⁶ Department of Fundamental Medicine, School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia; Laboratory of Pharmacology, National Scientific Center of Marine Biology, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia. Electronic address: igbryukhovetskiy@gmail.com.

PMID: 32448613
DOI: 10.1016/bs.irn.2020.03.010

Abstract

Glioblastoma is one of the most aggressive human brain tumors. Even following all the modern protocols of complex treatment, the median patient survival typically does not exceed 15 months. This review analyzes the main reasons for glioblastoma resistance to therapy, as well as attempts at categorizing the main approaches to increasing chemotherapy efficiency. Special emphasis is placed on the specific group of compounds, known as marine alkaloids and their synthetic derivatives exerting a general antitumor effect on glioblastoma cells. The unique mechanisms of marine alkaloid influence on the tumor cells prompt considering them as a promising basis for creating new chemotherapeutic agents for glioblastoma treatment.

Keywords: Chemotherapy; Fascaplysin; Glioblastoma multiforme; Temozolomide.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alkaloids / pharmacology*
Antineoplastic Agents / pharmacology*
Brain Neoplasms / drug therapy*
Glioblastoma / drug therapy*
Humans
Indoles / pharmacology*

Substances

Alkaloids
Antineoplastic Agents
Indoles
fascaplysine