Pneumoconiosis is an occupational disease which seriously endangers the health of workers exposed to dust. Silica is regarded as the most serious cause of pneumoconiosis because it can cause diffuse pulmonary fibrosis in workers' lung tissue. Mesenchymal stem cells (MSCs) are adult stem cells with multiple differentiation potential. As member of extracellular vesicles family, exosomes can be secreted from MSCs to regulate and intervene tumorigenesis, cardiovascular disease, immune system disorder and tissue damage disease. This article reviews the experimental results in the field of intervention of MSCs and its exosomes in silicosis research in recent years, which plays an important role in indicating direction in the future research on the mechanism and function of MSCs exosomes in the therapy of silica-induced pulmonary fibrosis.
尘肺是严重危害接尘工人健康的职业病，其中矽尘由于能够引起劳动者肺组织弥漫性纤维化而被视为危害严重的一种尘肺病诱发因素。间充质干细胞（MSCs）是具有多向分化潜能特点的成体干细胞，能够通过分泌胞外囊泡家族成员外泌体行使对肿瘤、心血管疾病、免疫系统疾病和组织损伤等重大疾病的干预和调控功能。本文综述了近年来MSCs及其外泌体在矽肺纤维化干预领域的研究成果，为今后利用MSCs及其外泌体治疗矽肺纤维化的机制和功能研究起到指示方向和策略建议的作用。.
Keywords: Exosomes; Mesenchymal stem cells; Pulmonary fibrosis; Silicosis.