Isolation and identification of an anti-inflammatory principle from Capparis spinosa

M S al-Said; E A Abdelsattar; S I Khalifa; F S el-Feraly

Isolation and identification of an anti-inflammatory principle from Capparis spinosa

Pharmazie. 1988 Sep;43(9):640-1.

Authors

M S al-Said¹, E A Abdelsattar, S I Khalifa, F S el-Feraly

Affiliation

¹ Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

PMID: 3244735

Abstract

The homologous polyprenols cappaprenol-12 (1), cappaprenol-13 (2) and cappaprenol-14 (3) with 12, 13 and 14 isoprene units, respectively, could be isolated by preparative HPLC from alcoholic extracts of Capparis spinosa. Testing 2 for its anti-inflammatory activity an inhibition of the carrageenan-induced paw edema in rats of 44 vs. 67% for the standard oxyphenbutazone was found.

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / analysis
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
Carrageenan
Edema / chemically induced
Edema / prevention & control
Magnetic Resonance Spectroscopy
Mass Spectrometry
Plant Extracts / analysis
Plants, Medicinal / analysis*
Rats
Saudi Arabia
Spectrophotometry, Infrared

Substances

Anti-Inflammatory Agents, Non-Steroidal
Plant Extracts
Carrageenan