Development of small-molecule inhibitors against hantaviruses

Microbes Infect. 2020 Jul-Aug;22(6-7):272-277. doi: 10.1016/j.micinf.2020.05.011. Epub 2020 May 20.

Abstract

Hantavirus (HV), a pathogen of animal infectious diseases that poses a threat to humans, has attracted extensive attention. Clinically, HV can cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS), between which HFRS is mostly in Eurasia, and HPS is mostly in the Americas. This paper reviews the research progress of small-molecule inhibitors of HV.

Keywords: Hantavirus; Peptide; Small-molecule compound.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antiviral Agents / pharmacology*
  • Hantavirus Infections / virology
  • Host-Pathogen Interactions / drug effects
  • Humans
  • Orthohantavirus / drug effects*
  • Orthohantavirus / physiology
  • Peptides / chemistry
  • Peptides / pharmacology
  • Small Molecule Libraries / pharmacology*
  • Viral Proteins / antagonists & inhibitors
  • Viral Proteins / chemistry
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Peptides
  • Small Molecule Libraries
  • Viral Proteins