High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa

AIDS. 2020 Aug 1;34(10):1567-1570. doi: 10.1097/QAD.0000000000002580.

Abstract

: Exposure of infants to antiretroviral drugs for prevention of mother-to-child transmission can induce resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). Data from nine national surveys of pretreatment drug resistance in children newly diagnosed with HIV show high levels of resistance to NRTIs included in first-line antiretroviral treatment (ART) regimens (dual abacavir-lamivudine/emtricitabine resistance). Additional research is needed to determine the impact of NRTI resistance on treatment response and optimize infant ART.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Africa South of the Sahara
  • Anti-HIV Agents* / therapeutic use
  • Drug Resistance, Viral*
  • Female
  • HIV Infections* / drug therapy
  • Humans
  • Infant
  • Infectious Disease Transmission, Vertical / prevention & control*
  • Reverse Transcriptase Inhibitors* / therapeutic use

Substances

  • Anti-HIV Agents
  • Reverse Transcriptase Inhibitors