Functional genomics describes a field of biology that uses a range of approaches for assessing gene function with high-throughput molecular, genetic, and cellular technologies. The near limitless potential for applying these concepts to study the activities of all genetic loci has completely upended how today's cancer biologists tackle drug target discovery. We provide an overview of contemporary functional genomics platforms, highlighting areas of distinction and complementarity across technologies, so as to aid in the development or interpretation of cancer-focused screening efforts.
Keywords: CRISPR/Cas9; RNAi; cancer; functional genomics; genetic screen; genome editing; oncology; transposon.
Copyright © 2020 Elsevier Inc. All rights reserved.