Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A∗32:01-positive vancomycin-induced DRESS sharing an HLA class II haplotype

Nontaya Nakkam; Andrew Gibson; Effie Mouhtouris; Katherine C Konvinse; Natasha E Holmes; Kyra Y Chua; Pooja Deshpande; Danmeng Li; David A Ostrov; Jason Trubiano; Elizabeth J Phillips

doi:10.1016/j.jaci.2020.04.056

Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A∗32:01-positive vancomycin-induced DRESS sharing an HLA class II haplotype

J Allergy Clin Immunol. 2021 Jan;147(1):403-405. doi: 10.1016/j.jaci.2020.04.056. Epub 2020 May 19.

Authors

Affiliations

¹ Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Vanderbilt University Medical Center, Nashville, Tenn.
² Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia.
³ Department of Infectious Diseases, Austin Health, University of Melbourne, Melbourne, Australia.
⁴ Vanderbilt University Medical Center, Nashville, Tenn.
⁵ Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia; School of Human Sciences, University of Western Australia, Western Australia, Australia.
⁶ Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Fla.
⁷ Department of Infectious Diseases, Austin Health, University of Melbourne, Melbourne, Australia; Peter McCallum Cancer Centre, Melbourne, Australia.
⁸ Vanderbilt University Medical Center, Nashville, Tenn; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia. Electronic address: elizabeth.j.phillips@vumc.org.

Abstract

All fifteen patients with HLA-A*32:01 restricted vancomycin-induced DRESS, showed negative ex vivo responses to dalbavancin however two showed cross-reactivity to teicoplanin and telavancin. Adjunctive diagnostic testing should be considered to detect potential cross-reactivity amongst glycopeptides.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aminoglycosides / administration & dosage
Aminoglycosides / adverse effects*
Drug Hypersensitivity Syndrome / genetics*
Drug Hypersensitivity Syndrome / immunology
HLA-A Antigens / genetics*
HLA-A Antigens / immunology
Haplotypes*
Humans
Lipoglycopeptides / administration & dosage
Lipoglycopeptides / adverse effects*
Teicoplanin / administration & dosage
Teicoplanin / adverse effects*
Vancomycin / administration & dosage
Vancomycin / adverse effects*

Substances

Aminoglycosides
HLA-A Antigens
HLA-A*32 antigen
Lipoglycopeptides
Teicoplanin
Vancomycin
telavancin

Abstract

Publication types

MeSH terms

Substances

Grants and funding