Reflections on DNA-encoded chemical libraries

Richard A Lerner; Dario Neri

doi:10.1016/j.bbrc.2020.04.080

Reflections on DNA-encoded chemical libraries

Biochem Biophys Res Commun. 2020 Jun 30;527(3):757-759. doi: 10.1016/j.bbrc.2020.04.080. Epub 2020 May 18.

Authors

Richard A Lerner¹, Dario Neri²

Affiliations

¹ Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA. Electronic address: rlerner@scripps.edu.
² Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog Weg 4, CH, 8093 Zurich, Switzerland. Electronic address: neri@pharma.ethz.ch.

PMID: 32439178
DOI: 10.1016/j.bbrc.2020.04.080

Abstract

In this short Editorial, we reflect on certain milestones that have led to the development of DNA-Encoded Chemical Libraries, while also providing a glimpse to future challenges and opportunities.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Combinatorial Chemistry Techniques / methods*
DNA / chemistry*
Drug Discovery
Ligands
Peptide Library
Small Molecule Libraries / chemical synthesis*
Small Molecule Libraries / chemistry

Substances

Ligands
Peptide Library
Small Molecule Libraries
DNA

Grants and funding

670603/ERC_/European Research Council/International