The NLRP3 inflammasome in progressive multiple sclerosis

Atsushi Kadowaki; Francisco J Quintana

doi:10.1093/brain/awaa135

The NLRP3 inflammasome in progressive multiple sclerosis

Brain. 2020 May 1;143(5):1286-1288. doi: 10.1093/brain/awaa135.

Authors

Atsushi Kadowaki¹, Francisco J Quintana^{1

2}

Affiliations

¹ Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
² Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Abstract

This scientific commentary refers to ‘NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients’, by Malhotra et al. (doi:10.1093/brain/awaa084).

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Demyelinating Diseases*
Humans
Inflammasomes
Multiple Sclerosis*
NLR Family, Pyrin Domain-Containing 3 Protein

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein
NLRP3 protein, human

Grants and funding

R01 ES029136/ES/NIEHS NIH HHS/United States