Therapeutic Vaccines for the Treatment of HIV

Zhilin Chen; Boris Julg

doi:10.1016/j.trsl.2020.04.008

Therapeutic Vaccines for the Treatment of HIV

Transl Res. 2020 Sep:223:61-75. doi: 10.1016/j.trsl.2020.04.008. Epub 2020 May 11.

Authors

Zhilin Chen¹, Boris Julg²

Affiliations

¹ Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
² Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Unit, Massachusetts General Hospital, Boston, MA, USA. Electronic address: BJULG@mgh.harvard.edu.

Abstract

Despite the success of anti-retroviral therapy (ART) in transforming HIV into a manageable disease, it has become evident that long-term ART will not eliminate the HIV reservoir and cure the infection. Alternative strategies to eradicate HIV infection, or at least induce a state of viral control and drug-free remission are therefore needed. Therapeutic vaccination aims to induce or enhance immunity to alter the course of a disease. In this review we provide an overview of the current state of therapeutic HIV vaccine research and summarize the obstacles that the field faces while highlighting potential ways forward for a strategy to cure HIV infection.

Keywords: Adaptive immune responses; HIV; HIV cure; Therapeutic vaccination.

Publication types

Review

MeSH terms

AIDS Vaccines / therapeutic use*
Cytotoxicity, Immunologic
Disease Reservoirs / virology
HIV Infections / drug therapy*
HIV Infections / immunology
Humans
T-Lymphocytes, Cytotoxic / cytology
T-Lymphocytes, Cytotoxic / immunology

Substances

AIDS Vaccines

Abstract

Publication types

MeSH terms

Substances

Grants and funding