Cytochalasans from endophytic fungus Diaporthe sp. SC-J0138

Xiaoli Yang; Ping Wu; Jinghua Xue; Hanxiang Li; Xiaoyi Wei

doi:10.1016/j.fitote.2020.104611

Cytochalasans from endophytic fungus Diaporthe sp. SC-J0138

Fitoterapia. 2020 Sep:145:104611. doi: 10.1016/j.fitote.2020.104611. Epub 2020 May 11.

Authors

Xiaoli Yang¹, Ping Wu², Jinghua Xue², Hanxiang Li², Xiaoyi Wei³

Affiliations

¹ Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China; University of Chinese Academy of Sciences, Yuquanlu 19A, Beijing 100049, People's Republic of China.
² Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China; Guangdong Provincial Key Laboratory of Digital Botanical Garden / Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
³ Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China; Guangdong Provincial Key Laboratory of Digital Botanical Garden / Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China. Electronic address: wxy@scbg.ac.cn.

PMID: 32437736
DOI: 10.1016/j.fitote.2020.104611

Abstract

Five new cytochalasans, diaporthichalasins D-H (1-5), along with five known cytochalasans (6-10) were isolated from solid cultures of the endophytic fungus Diaporthe sp. SC-J0138 isolated from the leaves of Cyclosorus parasiticus. Their structures were elucidated by analysis of spectroscopic data and theoretical calculations of electronic circular dichroism spectra. Compounds 1 and 5 showed noticeable cytotoxicity against human carcinoma A549, HeLa, and HepG2 cells. The structure-activity relationships in cytotoxicity were discussed for this group of compounds.

Keywords: Cyclosorus parasiticus; Cytochalasan; Cytotoxicity; Diaporthe sp.; Diaporthichalasin; Endophyte.

MeSH terms

A549 Cells
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Ascomycota / chemistry*
Biological Products / isolation & purification
Biological Products / pharmacology*
China
Cytochalasins / isolation & purification
Cytochalasins / pharmacology*
Endophytes / chemistry
HeLa Cells
Hep G2 Cells
Humans
MCF-7 Cells
Molecular Structure
Plant Leaves / microbiology
Structure-Activity Relationship
Tracheophyta / microbiology

Substances

Antineoplastic Agents
Biological Products
Cytochalasins