TRPA1-dependent calcium transients and CGRP release in DRG neurons require extracellular calcium

J Cell Biol. 2020 Jun 1;219(6):e201702151. doi: 10.1083/jcb.201702151.

Abstract

Shang et al. (2016. J. Cell Biol.https://doi.org/10.1083/jcb.201603081) reported that activation of lysosomal TRPA1 channels led to intracellular calcium transients and CGRP release from DRG neurons. We argue that both findings are more likely due to influx of insufficiently buffered extracellular calcium rather than lysosomal release.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Calcitonin Gene-Related Peptide / metabolism
  • Calcium* / metabolism
  • Ganglia, Spinal* / metabolism
  • Lysosomes / metabolism
  • Neurons / metabolism
  • TRPA1 Cation Channel / genetics

Substances

  • TRPA1 Cation Channel
  • Calcitonin Gene-Related Peptide
  • Calcium