Alert from a Distant Neighbor: Spread of Antiviral Immunity through Anion Channels

Julia Kazmierski; Christine Goffinet

doi:10.1016/j.immuni.2020.04.017

Alert from a Distant Neighbor: Spread of Antiviral Immunity through Anion Channels

Immunity. 2020 May 19;52(5):719-721. doi: 10.1016/j.immuni.2020.04.017.

Authors

Julia Kazmierski¹, Christine Goffinet²

Affiliations

¹ Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Berlin Institute of Health, 10178 Berlin, Germany.
² Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Berlin Institute of Health, 10178 Berlin, Germany. Electronic address: christine.goffinet@charite.de.

PMID: 32433941
DOI: 10.1016/j.immuni.2020.04.017

Abstract

Cytosolic DNA detection via the DNA sensor cGAS initiates a major cell-intrinsic response to infection and malignancies. In this issue of Immunity, Zhou et al. (2020) report that the catalytic product of cGAS, cGAMP, can alert bystander cells over large distances through its cell-to-cell transmission via volume-regulated anion channels.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Anions
Antiviral Agents*
Immunity, Innate
Interferons*
Nucleotides, Cyclic
Nucleotidyltransferases

Substances

Anions
Antiviral Agents
Nucleotides, Cyclic
cyclic guanosine monophosphate-adenosine monophosphate
Interferons
Nucleotidyltransferases