Polyhedral oligomeric silsesquioxane (POSS)-dendrimer hybrid materials have attracted great interest in the past ten years. The integration of inorganic POSS and organic dendrimer blocks in a single-phase material offers numerous possibilities to access desirable mechanical, optical, and biomedical properties for various applications. In this review article, we describe several kinds of POSS-dendrimer hybrid materials (POSS as the core, surface functionality, repeating unit of dendrimers and the POSS-dendron conjugates) with an emphasis on their synthetic strategies, tunable macroscopic properties, and potential applications. Moreover, the current trends, challenges and future directions of POSS-dendrimer hybrid materials are elaborated.