Search for a practical approach for detection of clopidogrel resistance: Comparison of light transmission aggregometry and INNOVANCE® PFA P2Y cartridge and correlation with CYP2C19 variants

Int J Lab Hematol. 2020 Aug;42(4):e189-e191. doi: 10.1111/ijlh.13240. Epub 2020 May 19.

Authors

Laura Heireman¹, Tinne Monteyne¹, Dimitri Hemelsoet², Ron H N van Schaik³, Katrien M J Devreese^{1

4}

Affiliations

¹ Coagulation Laboratory, Department of Laboratory Medicine, University Hospital Ghent, Ghent, Belgium.
² Department of Neurology, University Hospital Ghent, Ghent, Belgium.
³ Department of Clinical Chemistry, Erasmus Medical Centre, Rotterdam, The Netherlands.
⁴ Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.

PMID: 32427413
DOI: 10.1111/ijlh.13240

No abstract available

Publication types

Comparative Study
Letter

MeSH terms

Adult
Aged
Aged, 80 and over
Blood Platelets / enzymology*
Blood Platelets / pathology
Cardiovascular Diseases* / blood
Cardiovascular Diseases* / drug therapy
Cardiovascular Diseases* / genetics
Cardiovascular Diseases* / pathology
Clopidogrel* / administration & dosage
Clopidogrel* / pharmacokinetics
Cytochrome P-450 CYP2C19 / genetics*
Cytochrome P-450 CYP2C19 / metabolism
Drug Resistance / drug effects
Drug Resistance / genetics*
Female
Humans
Male
Middle Aged
Platelet Aggregation / drug effects*
Platelet Function Tests

Substances

Clopidogrel
CYP2C19 protein, human
Cytochrome P-450 CYP2C19