Cognitive Inhibition Correlates with Exercise-Induced Hypoalgesia After Aerobic Bicycling in Pain-Free Participants

H Gajsar; C Titze; K Konietzny; M Meyer; H B Vaegter; M I Hasenbring

doi:10.2147/JPR.S238718

Cognitive Inhibition Correlates with Exercise-Induced Hypoalgesia After Aerobic Bicycling in Pain-Free Participants

J Pain Res. 2020 Apr 29:13:847-858. doi: 10.2147/JPR.S238718. eCollection 2020.

Authors

H Gajsar¹, C Titze¹, K Konietzny¹, M Meyer², H B Vaegter^{3

4}, M I Hasenbring^{1

3}

Affiliations

¹ Mind and Pain in Motion Group, Department of Medical Psychology and Medical Sociology, Ruhr University Bochum, Bochum, Germany.
² School of Social Sciences, University of Mannheim, Mannheim, Germany.
³ Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
⁴ Pain Research Group, Pain Center, University Hospital Odense, Odense, Denmark.

Abstract

Purpose: Exercise-induced hypoalgesia (EIH) is the short-term reduction of pain sensitivity after a single bout of exercise. Descending pain inhibition has been proposed to at least partly underlie EIH. Cognitive inhibition is the ability to inhibit a pre-potent response and has in turn been associated with descending pain inhibition, as indexed by conditioned pain modulation. Therefore, we hypothesized that cognitive inhibition is associated with higher EIH.

Methods: In this cross-sectional study, 37 pain-free participants (16 male, age 27.75 ± 9.91) completed a stop-signal task assessing cognitive inhibition ability and a control condition in the first session. In the second session, pre-post-test design EIH was assessed by means of aerobic bicycling (15 min., 75% VO₂max) and isometric knee extension (90 sec, 30% MVC). EIH was assessed with pressure pain thresholds (PPT) and temporal summation of pain (TSP), each at the hand and at the leg. Correlational analyses quantified the associations between cognitive inhibition and EIH change scores.

Results: Better cognitive inhibition correlated with EIH change scores in PPTs after aerobic bicycling at the hand (r = -0.35, 95% CI: -0.57; -0.08, p =0.021), but not at the leg (rho = -0.10, 95% CI: -0.36; 0.18, p = 0.277). No correlations between cognitive inhibition and change in PPTs after isometric knee extension at the hand (rho = -0.03, 95% CI: -0.30; 0.25, p = 0.857) nor at the leg (rho = -0.03, 95% CI: -0.25; 0.30, p = 0.857) were observed. There were no EIH effects after isometric exercise and, generally, no effects of exercise on TSP.

Conclusion: This study provides preliminary evidence for the notion that cognitive inhibition might play a supportive role in EIH. Although these results are clearly in need of replication, they accord well with previously reported associations between cognitive inhibition, experimental pain and descending pain inhibition.

Keywords: descending pain inhibition; exercise-induced hypoalgesia; pressure pain threshold; response inhibition; stop-signal task; temporal summation of pain.