Pd(II)-Catalyzed Direct γ-C(sp3)-H Arylation between Free β2-Amino Esters and β3-Amino Esters and Aryl Iodides Using a Catalytic Transient Directing Group

Zhaohui Wang; Yangjie Fu; Qiyu Zhang; Hong Liu; Jiang Wang

doi:10.1021/acs.joc.0c00115

Pd(II)-Catalyzed Direct γ-C(sp³)-H Arylation between Free β²-Amino Esters and β³-Amino Esters and Aryl Iodides Using a Catalytic Transient Directing Group

J Org Chem. 2020 Jun 19;85(12):7683-7693. doi: 10.1021/acs.joc.0c00115. Epub 2020 Jun 4.

Authors

Zhaohui Wang^{1

2}, Yangjie Fu^{1

2}, Qiyu Zhang^{1

2}, Hong Liu^{1

2}, Jiang Wang²

Affiliations

¹ Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
² State Key Laboratory of Drug Research and Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.

PMID: 32423204
DOI: 10.1021/acs.joc.0c00115

Abstract

Pd(II)-catalyzed direct γ-C(sp³)-H arylation coupling with free β²-amino esters and β³-amino esters using a commercially available catalytic transient directing group has been developed. This approach features high efficiency, broad substrate tolerance, easily accessible starting materials, and mild reaction conditions.

Publication types

Research Support, Non-U.S. Gov't