The prevention and pharmacotherapy of infectious diseases are of great importance. Among others, infections caused by Pseudomonas aeruginosa have a high mortality rate. This bacterium is the third most common cause of nosocomial infections, and characteristics such as multiple virulence factors, ability to survive, environmental spread, and resistance to antibiotics have made it a potential pathogen, especially for people with compromised immune systems. Considering bacterial resistance to current medications, high cost, and side effects, the need to provide new and effective therapies is highlighted. Curcumin is a dietary polyphenolic compound that has a wide range of therapeutic properties, including antibacterial effects. It has been the subject of increasing research exploring its potential utility in infectious diseases. In this review, the antibacterial effects of curcumin against Pseudomonas aeruginosa are discussed.