Monte Carlo Simulator for Diffusion-weighted Imaging Sequences

Magn Reson Med Sci. 2021 Jun 1;20(2):222-226. doi: 10.2463/mrms.bc.2020-0013. Epub 2020 May 18.

Abstract

We developed a Monte Carlo simulator for diffusion-weighted imaging sequences which displays the motion of water molecules and computes the dynamic phase dispersion due to the applied motion probing gradients. This simulator can be used to validate the analytical equations of diffusion models and understand their limitations due to their approximations. Here, we introduce the software and some specific use cases. The software can be downloaded from the following website: https://www.nirs.qst.go.jp/amr_diag.

Keywords: Monte Carlo simulation; diffusion-time; diffusion-weighted imaging; double diffusion encoding; water exchange.

MeSH terms

  • Cell Membrane / metabolism*
  • Computer Simulation*
  • Diffusion
  • Diffusion Magnetic Resonance Imaging / methods*
  • Humans
  • Monte Carlo Method
  • Motion*
  • Water / metabolism*

Substances

  • Water