Ultrasensitive detection of hydrogen peroxide and dopamine using copolymer-grafted metal-organic framework based electrochemical sensor

Shamim Ahmed Hira; Muthuchamy Nallal; Karkuzhali Rajendran; Sehwan Song; Sungkyun Park; Jae-Myung Lee; Sang Hoon Joo; Kang Hyun Park

doi:10.1016/j.aca.2020.04.043

Ultrasensitive detection of hydrogen peroxide and dopamine using copolymer-grafted metal-organic framework based electrochemical sensor

Anal Chim Acta. 2020 Jun 29:1118:26-35. doi: 10.1016/j.aca.2020.04.043. Epub 2020 Apr 21.

Authors

Shamim Ahmed Hira¹, Muthuchamy Nallal¹, Karkuzhali Rajendran², Sehwan Song³, Sungkyun Park³, Jae-Myung Lee⁴, Sang Hoon Joo⁵, Kang Hyun Park⁶

Affiliations

¹ Department of Chemistry, Pusan National University, Busan, 46241, South Korea.
² Department of Industrial Chemistry, Alagappa University, Karaikudi, 630003, Tamil Nadu, India.
³ Department of Physics, Pusan National University, Busan, 46241, South Korea.
⁴ Department of Naval Architecture, Pusan National University, Busan, 46241, South Korea.
⁵ Department of Energy Engineering and School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), 50 UNIST-gil, Ulsan, 44919, South Korea.
⁶ Department of Chemistry, Pusan National University, Busan, 46241, South Korea. Electronic address: chemistry@pusan.ac.kr.

PMID: 32418601
DOI: 10.1016/j.aca.2020.04.043

Abstract

We reported the synthesis of a copolymer- and metal-organic framework-based electrochemical sensor, UiO-66-NH₂@P(ANI-co-ANA) using the polymerization method for the highly sensitive and selective detection of hydrogen peroxide (H₂O₂) and dopamine (DA). The as-synthesized material was characterized via Fourier transform infrared spectroscopy, X-ray diffraction analysis, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, and thermogravimetric analysis. The electrochemical characteristics of the proposed sensor were evaluated via impedance spectroscopy and cyclic voltammetry (CV). The electrochemical oxidation of DA and the reduction of H₂O₂ were determined via CV, square-wave voltammetry, and chronoamperometric techniques. The fabricated sensor exhibited a wide linear range of 25-500 μM, with a sensitivity of 1396.1 μAμM^-1cm^-2 and a limit of detection of 0.6 μM, for the electrochemical reduction of H₂O₂. Additionally, it exhibited a wide linear range of 10-110 μM, with a sensitivity of 1110.2 μAμM^-1cm^-2 and a limit of detection of 0.3 μM, for the electrochemical detection of DA. The practical utility of the fabricated sensor was evaluated via the detection of H₂O₂ in milk samples and DA in human urine samples.

Keywords: Dopamine; Hydrogen peroxide; Metal-organic framework; Polymerization; Sensor.

MeSH terms

Dopamine / analysis*
Electrochemical Techniques*
Hydrogen Peroxide / analysis*
Metal-Organic Frameworks / chemical synthesis
Metal-Organic Frameworks / chemistry*
Molecular Structure
Polymers / chemical synthesis
Polymers / chemistry*

Substances

Metal-Organic Frameworks
Polymers
Hydrogen Peroxide
Dopamine