Human Herpesvirus 6 Detection during the Evaluation of Sepsis in Infants Using the FilmArray Meningitis/Encephalitis Panel

J Pediatr. 2020 Aug:223:204-206.e1. doi: 10.1016/j.jpeds.2020.03.023. Epub 2020 May 13.

Abstract

We used the FilmArray meningitis/encephalitis panel for evaluation of sepsis in febrile neonates. We detected human herpesvirus 6, a virus we did not routinely test for previously, in the cerebrospinal fluid of 7 neonates. In all 7 cases, detection of the virus did not warrant antiviral treatment.

Keywords: molecular diagnostics; neonatal fever.

Publication types

  • Case Reports

MeSH terms

  • DNA, Viral / analysis*
  • Encephalitis / complications*
  • Encephalitis / diagnosis
  • Encephalitis / virology
  • Female
  • Herpesvirus 6, Human / genetics*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Meningitis / complications
  • Meningitis / diagnosis*
  • Multiplex Polymerase Chain Reaction
  • Roseolovirus Infections / complications
  • Roseolovirus Infections / diagnosis*
  • Roseolovirus Infections / virology
  • Sepsis / diagnosis
  • Sepsis / etiology
  • Sepsis / virology*
  • Tertiary Care Centers*

Substances

  • DNA, Viral