How microRNAs affect the PD-L1 and its synthetic pathway in cancer

Gholamreza Rezaei Danbaran; Saeed Aslani; Nadia Sharafkandi; Maryam Hemmatzadeh; Ramin Hosseinzadeh; Gholamreza Azizi; Farhad Jadidi-Niaragh; Farhad Babaie; Hamed Mohammadi

doi:10.1016/j.intimp.2020.106594

How microRNAs affect the PD-L1 and its synthetic pathway in cancer

Int Immunopharmacol. 2020 Jul:84:106594. doi: 10.1016/j.intimp.2020.106594. Epub 2020 May 12.

Authors

Gholamreza Rezaei Danbaran¹, Saeed Aslani², Nadia Sharafkandi³, Maryam Hemmatzadeh⁴, Ramin Hosseinzadeh², Gholamreza Azizi⁵, Farhad Jadidi-Niaragh⁶, Farhad Babaie⁷, Hamed Mohammadi⁸

Affiliations

¹ Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
² Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
³ Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
⁴ Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
⁵ Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
⁶ Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁷ Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran.
⁸ Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran; Department of Immunology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. Electronic address: h.mohammadi@abzums.ac.ir.

PMID: 32416456
DOI: 10.1016/j.intimp.2020.106594

Abstract

Programmed cell death-ligand 1 (PD-L1) is a glycoprotein that is expressed on the cell surface of both hematopoietic and nonhematopoietic cells. PD-L1 play a role in the immune tolerance and protect self-tissues from immune system attack. Dysfunction of this molecule has been highlighted in the pathogenesis of tumors, autoimmunity, and infectious disorders. MicroRNAs (miRNAs) are endogenous molecules that are classified as small non-coding RNA with approximately 20-22 nucleotides (nt) length. The function of miRNAs is based on complementary interactions with target mRNA via matching completely or incompletely. The result of this function is decay of the target mRNA or preventing mRNA translation. In the past decades, several miRNAs have been discovered which play an important role in the regulation of PD-L1 in various malignancies. In this review, we discuss the effect of miRNAs on PD-L1 expression and consider the effect of miRNAs on the synthetic pathway of PD-L1, especially during cancers.

Keywords: Cancer therapy; Immune suppression; Immune system; PD-L1; microRNA.

Publication types

Review

MeSH terms

Animals
B7-H1 Antigen / biosynthesis*
Humans
MicroRNAs*
Neoplasms / genetics*
Neoplasms / immunology*

Substances

B7-H1 Antigen
MicroRNAs