Binge Drinking: Macropinocytosis Promotes Tumorigenic Growth of RAS-Mutant Cancers

G Aaron Hobbs; Channing J Der

doi:10.1016/j.tibs.2020.02.009

Binge Drinking: Macropinocytosis Promotes Tumorigenic Growth of RAS-Mutant Cancers

Trends Biochem Sci. 2020 Jun;45(6):459-461. doi: 10.1016/j.tibs.2020.02.009. Epub 2020 Mar 9.

Authors

G Aaron Hobbs¹, Channing J Der²

Affiliations

¹ University of North Carolina at Chapel Hill, Department of Pharmacology, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.
² University of North Carolina at Chapel Hill, Department of Pharmacology, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA. Electronic address: cjder@med.unc.educjder@med.unc.edu(@cjder23).

PMID: 32413322
DOI: 10.1016/j.tibs.2020.02.009

Abstract

The RAS oncoprotein drives elevated macropinocytosis, a metabolic process essential for cancer growth. A recent study by Ramirez et al. elucidated a mechanism whereby RAS controls V-ATPase association with the plasma membrane to drive RAC1 GTPase-dependent macropinocytosis. Potentially actionable targets to disrupt this RAS-dependent nutrient acquisition pathway were identified.

Keywords: KRAS; SLC4A7; V-ATPase; cancer metabolism; macropinocytosis.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Adenosine Triphosphatases
Binge Drinking*
Cell Membrane
Humans
Neoplasms* / genetics
Pinocytosis

Substances

Adenosine Triphosphatases

Abstract

Publication types

MeSH terms

Substances

Grants and funding