RNA N6-Methyladenosine Modifications and the Immune Response

Ya-Nan Wang; Chen-Yang Yu; Hong-Zhong Jin

doi:10.1155/2020/6327614

RNA N⁶-Methyladenosine Modifications and the Immune Response

J Immunol Res. 2020 Jan 21:2020:6327614. doi: 10.1155/2020/6327614. eCollection 2020.

Authors

Ya-Nan Wang¹, Chen-Yang Yu¹, Hong-Zhong Jin¹

Affiliation

¹ Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy Medical Science and Peking Union Medical College, Beijing, China.

Abstract

N⁶-methyladenosine (m⁶A) is the most important modification of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) in higher eukaryotes. Modulation of m⁶A modifications relies on methyltransferases and demethylases. The discovery of binding proteins confirms that the m⁶A modification has a wide range of biological effects and significance at the molecular, cellular, and physiological levels. In recent years, techniques for investigating m⁶A modifications of RNA have developed rapidly. This article reviews the biological significance of RNA m⁶A modifications in the innate immune response, adaptive immune response, and viral infection.

Publication types

Review

MeSH terms

Adaptive Immunity / genetics*
Adenosine / analogs & derivatives*
Adenosine / metabolism
Animals
Epigenesis, Genetic / immunology*
Host Microbial Interactions / genetics
Host Microbial Interactions / immunology
Humans
Immunity, Innate / genetics*
RNA, Long Noncoding / genetics
RNA, Long Noncoding / metabolism
RNA, Messenger / genetics
RNA, Messenger / metabolism
Virus Diseases / genetics*
Virus Diseases / immunology

Substances

RNA, Long Noncoding
RNA, Messenger
N-methyladenosine
Adenosine