Developmental Mutators and Early Onset Cancer

Alex Kentsis; Steven A Frank

doi:10.3389/fped.2020.00189

Developmental Mutators and Early Onset Cancer

Front Pediatr. 2020 Apr 28:8:189. doi: 10.3389/fped.2020.00189. eCollection 2020.

Authors

Alex Kentsis¹, Steven A Frank²

Affiliations

¹ Sloan Kettering Institute and Department of Pediatrics, Weill Medical College of Cornell University and Memorial Sloan Kettering Cancer Center, New York, NY, United States.
² Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA, United States.

Abstract

A new hypothesis suggests that somatic genome remodeling during normal development can cause mutations that explain many early onset cancers in children and adults.

Keywords: cancer genetics and genomics; childhood cancer; developmental plasticity; mosaicism; prevention.

Abstract

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