Case report; meta-synchronous triple malignancy in primary diagnosed CML patient

Esraa Jamal; Shaimaa El-Ashwah; Mohamed A Ebrahim; Marwa Ma Zaki; Layla'M Saleh; Adel El-Badrawy; Emad Azmy

Case report; meta-synchronous triple malignancy in primary diagnosed CML patient

Am J Blood Res. 2020 Apr 15;10(2):22-25. eCollection 2020.

Authors

Esraa Jamal¹, Shaimaa El-Ashwah¹, Mohamed A Ebrahim², Marwa Ma Zaki³, Layla'M Saleh⁴, Adel El-Badrawy⁵, Emad Azmy¹

Affiliations

¹ Clinical Hematology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University Egypt.
² Medical Oncology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University Egypt.
³ Pathology Department, Faculty of Medicine, Mansoura University Egypt.
⁴ Clinical Pathology Unit, Faculty of Medicine, Mansoura University Egypt.
⁵ Diagnostic and Interventional Radiology Department, Faculty of Medicine, Mansoura University Egypt.

PMID: 32411499
PMCID: PMC7218681

Abstract

The diagnosis of different types of cancer in a single patient has been appeared in the field in some case reports involving different categories of cancer types either appeared at the same time (synchronous) or subsequently (meta-synchronous). The aim of this report is to present this interesting case of male patient who was under treatment of CML then T-lymphoblastic lymphoma and HCC discovered subsequently. CML, Lymphoma and HCC are arising from different lines of cells with different biology and cytogenetic criteria. CML and acute lymphoblastic leukemia may occur together in cases of blastic crisis of CML. But, they rarely occur together as separate multiple malignancies especially without any history of exposure to ionizing radiation, chemotherapy or transplantation.

Keywords: Chronic myeloid leukemia; T-lymphoblastic lymphoma; hepatitis C virus; hepatocellular carcinoma; tyrosine kinase inhibitor.

Publication types

Case Reports