Guanidiniocarbonyl-Pyrroles (GCP) - 20 Years of the Schmuck Binding Motif

Michael Giese; Jochen Niemeyer; Jens Voskuhl

doi:10.1002/cplu.202000142

Guanidiniocarbonyl-Pyrroles (GCP) - 20 Years of the Schmuck Binding Motif

Chempluschem. 2020 May;85(5):985-997. doi: 10.1002/cplu.202000142.

Authors

Michael Giese¹, Jochen Niemeyer¹, Jens Voskuhl¹

Affiliation

¹ Faculty of Chemistry, Organic Chemistry, University of Duisburg-Essen, Universitätsstrasse 7, 45117, Essen, Germany.

PMID: 32410387
DOI: 10.1002/cplu.202000142

Abstract

In this Minireview, an overview about the past 20 years of the guanidiniocarbonyl-pyrrole (GCP) binding motif, which was designed, investigated and applied by Prof. Dr. Carsten Schmuck, is presented. Here we highlight the first steps from design and discovery, initial binding studies, applications in material science to advanced biomedical use in protein modulation and delivery of genetic material.

Keywords: Gels; materials; protein recognition; supramolecular chemistry; transfection.

Publication types

Review
Research Support, Non-U.S. Gov't