Surface modification of carbon nanotube with gelatin via mussel inspired method

Dongfang Li; Saiyu Li; Jia Liu; Lilin Zhan; Pei Wang; Hongshui Zhu; Junchao Wei

doi:10.1016/j.msec.2020.110887

Surface modification of carbon nanotube with gelatin via mussel inspired method

Mater Sci Eng C Mater Biol Appl. 2020 Jul:112:110887. doi: 10.1016/j.msec.2020.110887. Epub 2020 Mar 21.

Authors

Dongfang Li¹, Saiyu Li¹, Jia Liu², Lilin Zhan¹, Pei Wang¹, Hongshui Zhu³, Junchao Wei⁴

Affiliations

¹ School of Stomatology, Nanchang University, Nanchang 330006, China; The Key Laboratory of Oral Biomedicine, Jiangxi Province, Nanchang 330006, China.
² College of Chemistry, Nanchang University, Nanchang 330031, China.
³ School of Stomatology, Nanchang University, Nanchang 330006, China; The Key Laboratory of Oral Biomedicine, Jiangxi Province, Nanchang 330006, China. Electronic address: zhuhongshui@126.com.
⁴ School of Stomatology, Nanchang University, Nanchang 330006, China; The Key Laboratory of Oral Biomedicine, Jiangxi Province, Nanchang 330006, China; College of Chemistry, Nanchang University, Nanchang 330031, China. Electronic address: weijunchao@ncu.edu.cn.

PMID: 32409043
DOI: 10.1016/j.msec.2020.110887

Abstract

Carbon nanotube (CNT) has aroused much attention in biomedical field. However, the cytotoxicity and aggregation are critical factors that affect the application of carbon nanotube (CNT). Herein, gelatin was grafted on the surface of CNT via mussel-inspired method. The gelatin modified CNT can disperse homogeneously in water. The in vitro test showed that gelatin modified CNT showed much better biocompatibility than the native CNT, which may improve its potential application in biomedical field.

Keywords: Biocompatibility; Carbon nanotube; Gelatin; Poly(dopamine); Surface modification.

MeSH terms

Animals
Biocompatible Materials / chemistry*
Biocompatible Materials / pharmacology
Cell Line
Cell Survival / drug effects
Gelatin / chemistry*
Indoles / chemistry
Mice
Nanotubes, Carbon / chemistry*
Polymers / chemistry
Surface Properties

Substances

Biocompatible Materials
Indoles
Nanotubes, Carbon
Polymers
polydopamine
Gelatin