Finding Their Type: Elusive Antigenic Sites on Dengue Virus 3 Mapped with Human Antibodies

Vanessa V Sarathy; Alan D T Barrett

doi:10.1016/j.chom.2020.04.015

Finding Their Type: Elusive Antigenic Sites on Dengue Virus 3 Mapped with Human Antibodies

Cell Host Microbe. 2020 May 13;27(5):681-682. doi: 10.1016/j.chom.2020.04.015.

Authors

Vanessa V Sarathy¹, Alan D T Barrett²

Affiliations

¹ Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: vvsarath@utmb.edu.
² Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: abarrett@utmb.edu.

PMID: 32407701
DOI: 10.1016/j.chom.2020.04.015

Abstract

In this issue of Cell Host & Microbe, Young et al. shed light on dengue virus 3-specific epitopes. Mapping of human monoclonal antibodies led to the discovery of six quaternary antigenic sites with strong neutralizing activity suggesting that epitopes involved with protective immunity may be more complex than previously realized.

Publication types

Comment

MeSH terms

Antibodies, Neutralizing*
Antibodies, Viral
Dengue Virus / immunology*
Epitopes
Humans
Serogroup

Substances

Antibodies, Neutralizing
Antibodies, Viral
Epitopes