Fine Particulate Matter Air Pollution and Mortality among Pediatric, Adolescent, and Young Adult Cancer Patients

Abstract

Background: Air pollution is a carcinogen and causes pulmonary and cardiac complications. We examined the association of fine particulate matter pollution (PM_2.5) and mortality from cancer and all causes among pediatric, adolescent, and young adult (AYA) patients with cancer in Utah, a state with considerable variation in PM_2.5.

Methods: We followed 2,444 pediatric (diagnosed ages 0-14) and 13,459 AYA (diagnosed ages 15-39) patients diagnosed in 1986-2015 from diagnosis to 5 and 10 years postdiagnosis, death, or emigration. We measured average monthly PM_2.5 by ZIP code during follow-up. Separate pediatric and AYA multivariable Cox models estimated the association of PM_2.5 and mortality. Among AYAs, we examined effect modification of PM_2.5 and mortality by stage while controlling for cancer type.

Results: Increases in PM_2.5 per 5 μg/m³ were associated with cancer mortality in pediatric lymphomas and central nervous system (CNS) tumors at both time points, and all cause mortality in lymphoid leukemias [HR_5-year = 1.32 (1.02-1.71)]. Among AYAs, PM_2.5 per 5 μg/m³ was associated with cancer mortality in CNS tumors and carcinomas at both time points, and all cause mortality for all AYA cancer types [HR_5-year = 1.06 (1.01-1.13)]. PM_2.5 ≥12 μg/m³ was associated with cancer mortality among breast [HR_5-year = 1.50 (1.29-1.74); HR_10-year = 1.30 (1.13-1.50)] and colorectal cancers [HR_5-year = 1.74 (1.29-2.35); HR_10-year = 1.67 (1.20-2.31)] at both time points. Effect modification by stage was significant, with local tumors at highest risk.

Conclusions: PM_2.5 was associated with mortality in pediatric and AYA patients with specific cancers.

Impact: Limiting PM_2.5 exposure may be important for young cancer patients with certain cancers.See all articles in this CEBP Focus section, "Environmental Carcinogenesis: Pathways to Prevention."