Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?

Cell Calcium. 2020 Jun:88:102212. doi: 10.1016/j.ceca.2020.102212. Epub 2020 May 6.

Abstract

The ongoing SARS-CoV2 outbreak has developed into a global pandemic. Despite previous outbreaks of SARS-CoV and the related MERS-CoV in recent years, neither a vaccine nor any other medication for an effective treatment are currently available. Endo-lysosomal two-pore cation channels have now emerged as potential novel targets for SARS-CoV treatment.

Keywords: Covid-19; Lysosome; SARS-CoV2; TPC; TPC2; Two-pore channel.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Betacoronavirus / drug effects
  • Betacoronavirus / metabolism*
  • COVID-19
  • Calcium Channel Blockers / pharmacology
  • Calcium Channel Blockers / therapeutic use
  • Calcium Channels / metabolism
  • Coronavirus Infections / drug therapy
  • Coronavirus Infections / metabolism*
  • Humans
  • Ion Channels / antagonists & inhibitors*
  • Ion Channels / metabolism*
  • Lysosomes / drug effects
  • Lysosomes / metabolism*
  • Middle East Respiratory Syndrome Coronavirus / drug effects
  • Middle East Respiratory Syndrome Coronavirus / metabolism
  • Pandemics
  • Pneumonia, Viral / drug therapy
  • Pneumonia, Viral / metabolism*
  • Protein Transport / drug effects
  • Protein Transport / physiology
  • SARS-CoV-2
  • Severe Acute Respiratory Syndrome / drug therapy
  • Severe Acute Respiratory Syndrome / metabolism

Substances

  • Calcium Channel Blockers
  • Calcium Channels
  • Ion Channels
  • TPCN1 protein, human
  • TPCN2 protein, human