Abstract
The ongoing SARS-CoV2 outbreak has developed into a global pandemic. Despite previous outbreaks of SARS-CoV and the related MERS-CoV in recent years, neither a vaccine nor any other medication for an effective treatment are currently available. Endo-lysosomal two-pore cation channels have now emerged as potential novel targets for SARS-CoV treatment.
Keywords:
Covid-19; Lysosome; SARS-CoV2; TPC; TPC2; Two-pore channel.
© 2020 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Betacoronavirus / drug effects
-
Betacoronavirus / metabolism*
-
COVID-19
-
Calcium Channel Blockers / pharmacology
-
Calcium Channel Blockers / therapeutic use
-
Calcium Channels / metabolism
-
Coronavirus Infections / drug therapy
-
Coronavirus Infections / metabolism*
-
Humans
-
Ion Channels / antagonists & inhibitors*
-
Ion Channels / metabolism*
-
Lysosomes / drug effects
-
Lysosomes / metabolism*
-
Middle East Respiratory Syndrome Coronavirus / drug effects
-
Middle East Respiratory Syndrome Coronavirus / metabolism
-
Pandemics
-
Pneumonia, Viral / drug therapy
-
Pneumonia, Viral / metabolism*
-
Protein Transport / drug effects
-
Protein Transport / physiology
-
SARS-CoV-2
-
Severe Acute Respiratory Syndrome / drug therapy
-
Severe Acute Respiratory Syndrome / metabolism
Substances
-
Calcium Channel Blockers
-
Calcium Channels
-
Ion Channels
-
TPCN1 protein, human
-
TPCN2 protein, human