New meroterpenoid compounds from the culture of mushroom Panus lecomtei

Si-Xian Wang; Rui-Lin Zhao; Cui Guo; Bao-Song Chen; Huan-Qin Dai; Gao-Qiang Liu; Hong-Wei Liu

doi:10.1016/S1875-5364(20)30033-9

New meroterpenoid compounds from the culture of mushroom Panus lecomtei

Chin J Nat Med. 2020 Apr;18(4):268-272. doi: 10.1016/S1875-5364(20)30033-9.

Authors

Si-Xian Wang¹, Rui-Lin Zhao², Cui Guo², Bao-Song Chen², Huan-Qin Dai², Gao-Qiang Liu³, Hong-Wei Liu⁴

Affiliations

¹ Hunan Provincial Key Laboratory of Forestry Biotechnology & International Cooperation Base of Science and Technology Innovation on Forest Resource Biotechnology, Central South University of Forestry & Technology, Changsha 410004, China; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
² State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Savaid Medicine School, University of Chinese Academy of Sciences, Beijing 100049, China.
³ Hunan Provincial Key Laboratory of Forestry Biotechnology & International Cooperation Base of Science and Technology Innovation on Forest Resource Biotechnology, Central South University of Forestry & Technology, Changsha 410004, China. Electronic address: gaoliuedu@csuft.edu.cn.
⁴ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Savaid Medicine School, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: liuhw@im.ac.cn.

PMID: 32402403
DOI: 10.1016/S1875-5364(20)30033-9

Abstract

Two new meroterpenoid compounds (1 and 2) together with five known meroterpenoid derivatives (3-7) were isolated from solid culture of mushroom Panus lecomtei. The structures of new compounds were confirmed by the analysis of NMR and HR-ESI-MS spectroscopic data. The biosynthetic pathway of 1-7 was postulated. All isolated compounds were evaluated for antibacterial activities against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa and Bacillus Calmette-Guérin. Compound 3 exhibited weak antibacterial activity against Bacillus Calmette-Guérin with the inhibition rate of 83.6% at 100 μmol·L^-1. Other compounds showed no antibacterial activities against all tested pathogens at 100 μmol·L^-1.

Keywords: Antibacterial; Biosynthetic pathway; Meroterpenoid; Panus lecomtei.

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology*
Bacteria / drug effects*
China
Molecular Structure
Plant Extracts / chemistry*
Polyporales / chemistry*
Terpenes / chemistry*
Terpenes / isolation & purification

Substances

Anti-Bacterial Agents
Plant Extracts
Terpenes

Supplementary concepts

Panus lecomtei