The specific characteristics of the Federal District (DF) favor the introduction, reproduction, dissemination, and permanence of dengue vector and viruses. Here, we aimed to analyze the spatiotemporal patterns of dengue epidemics in the Administrative Regions (RAs) of the DF from January 2007 to December 2017. We used Fourier partial series model to obtain a seasonal signature of the time series, which allowed calculating indicators of permanence (number of epidemic years, number of epidemic months per year, the proportion of epidemic months for the period) and time/moment of epidemics (month of epidemic peak). A total of 82 epidemics were recorded in this period. The RAs with the largest number of epidemic years were Varjão (5 epidemics), Gama, Lago Sul, and Sobradinho (4 epidemics). These last three RAs also had the highest proportions of epidemic months of the entire study period (9 epidemic months). The RAs with urban centrality function had an earlier epidemic peak than the others, in February and March. Epidemics showed high permanence values in RAs with different types of occupations, emphasizing the need to consider the social organization of space processes in dengue distribution studies.