Emerging Concepts of Nanobiotechnology in mRNA Delivery

Yue Wang; Chengzhong Yu

doi:10.1002/anie.202003545

Emerging Concepts of Nanobiotechnology in mRNA Delivery

Angew Chem Int Ed Engl. 2020 Dec 21;59(52):23374-23385. doi: 10.1002/anie.202003545. Epub 2020 Sep 9.

Authors

Yue Wang¹, Chengzhong Yu^{1

2}

Affiliations

¹ Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
² School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.

PMID: 32400110
DOI: 10.1002/anie.202003545

Abstract

Introducing mRNA into cells has attracted intense interest for diverse applications; however, success requires delivery solutions. Engineered nanomaterials have been applied as mRNA nanocarriers; their functions are designed mainly as delivery vehicles, but rarely in regulation of the protein translation. Recently, progress in nanobiotechnology has shifted the design principle of mRNA nanocarriers from simple delivery tools to translation modulators. Here, we review the emerging concepts of nanomaterials regulating mRNA translation and recent progress in mRNA delivery. Designer nanomaterials providing integrated functions for specific mRNA applications are also reviewed to provide insights for the design of next-generation nanomaterials to revolutionize mRNA technology.

Keywords: functional materials; mRNA delivery; nanotechnology; regulated translation; structure-function relationship.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Drug Delivery Systems / methods*
Humans
Nanotechnology / methods*
RNA, Messenger / metabolism*

Substances

RNA, Messenger