Cohesin Biology: From Passive Rings to Molecular Motors

Nina Mayerova; Lubos Cipak; Juraj Gregan

doi:10.1016/j.tig.2020.03.001

Cohesin Biology: From Passive Rings to Molecular Motors

Trends Genet. 2020 Jun;36(6):387-389. doi: 10.1016/j.tig.2020.03.001. Epub 2020 Mar 31.

Authors

Nina Mayerova¹, Lubos Cipak², Juraj Gregan³

Affiliations

¹ Department of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, 842 15 Bratislava, Slovakia.
² Department of Genetics, Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovakia.
³ Advanced Microscopy Facility, VBCF, Vienna Biocenter (VBC), Dr. Bohr-Gasse 9, 1030 Vienna, Austria; Department of Chromosome Biology, MPL, University of Vienna, Vienna Biocenter (VBC), Dr. Bohr-Gasse 9, 1030 Vienna, Austria. Electronic address: juraj.gregan@univie.ac.at.

PMID: 32396831
DOI: 10.1016/j.tig.2020.03.001

Abstract

The loop extrusion hypothesis postulated that extrusion of DNA loops through cohesin rings organizes genomes. Recent findings suggest that cohesin itself is a molecular motor that extrudes DNA. This has important implications not only for the organization of interphase chromatin but also for other processes where cohesin plays vital roles.

Keywords: SMC complex; cohesin; loop extrusion; meiosis; recombination.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Cycle Proteins / genetics
Cell Cycle Proteins / metabolism*
Cell Nucleus / genetics*
Chromatin Assembly and Disassembly*
Chromosomal Proteins, Non-Histone / genetics
Chromosomal Proteins, Non-Histone / metabolism*
Cohesins
DNA Packaging
DNA Replication*
Humans
Meiosis*

Substances

Cell Cycle Proteins
Chromosomal Proteins, Non-Histone