Repetitive Elements: Different Subtypes Hint at Distinct Functions

Zhenyu Zuo; Pedro P Rocha

doi:10.1016/j.tig.2020.03.008

Repetitive Elements: Different Subtypes Hint at Distinct Functions

Trends Genet. 2020 Jun;36(6):385-387. doi: 10.1016/j.tig.2020.03.008. Epub 2020 Apr 6.

Authors

Zhenyu Zuo¹, Pedro P Rocha²

Affiliations

¹ Unit on Genome Structure and Regulation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
² Unit on Genome Structure and Regulation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA; National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: pedrorocha@nih.gov.

PMID: 32396830
DOI: 10.1016/j.tig.2020.03.008

Abstract

Lu et al. report that the association of different repeat types with distinct gene classes goes far beyond what has previously been shown and suggest that such relationship might be essential for gene function and regulation. As an example, they describe how long interspersed nuclear repeat (LINE1) transcripts are recruited together with associated genes to silent nuclear regions.

Keywords: LADs/NADs; LINE1; gene function; gene regulation; repetitive elements; transposons.

Published by Elsevier Ltd.

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MeSH terms

Repetitive Sequences, Nucleic Acid*