Abstract
A double conjugation strategy was implemented to produce an anti-fentanyl vaccine, which was predicated upon preformed-antibody-assisted antigen presentation. The new vaccine was found to reduce the psychoactive effects of fentanyl without the addition of the immunostimulant CpG oligodeoxynucleotide.
MeSH terms
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Animals
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Antibodies / blood*
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Antibodies / immunology
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Antibodies / metabolism
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Disaccharides / chemistry*
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Disaccharides / immunology
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Epitopes / immunology
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Fentanyl / chemistry
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Fentanyl / immunology*
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Immunity
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Mice
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Vaccines, Synthetic / chemistry
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Vaccines, Synthetic / immunology*
Substances
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Antibodies
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Disaccharides
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Epitopes
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Vaccines, Synthetic
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galactosyl-(1-3)galactose
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Fentanyl