Isavuconazole Therapy of Disseminated and Encephalic Saprochaete Capitata Infection in an Acute Myeloid Leukemia Patient Treated with Midostaurin

Salvatore Perrone; Chiara Lisi; Elettra Ortu La Barbera; Cristina Luise; Miriam Lichtner; Corrado Girmenia; Giuseppe Cimino

doi:10.4084/MJHID.2020.026

Isavuconazole Therapy of Disseminated and Encephalic Saprochaete Capitata Infection in an Acute Myeloid Leukemia Patient Treated with Midostaurin

Mediterr J Hematol Infect Dis. 2020 May 1;12(1):e2020026. doi: 10.4084/MJHID.2020.026. eCollection 2020.

Authors

Salvatore Perrone¹, Chiara Lisi¹, Elettra Ortu La Barbera¹, Cristina Luise¹, Miriam Lichtner², Corrado Girmenia³, Giuseppe Cimino^{1

4}

Affiliations

¹ Hematology, Polo Universitario Pontino, S.M. Goretti Hospital, Latina, Italy.
² Department of Public Health and Infectious Diseases, Sapienza University, S.M. Goretti Hospital, Latina, Italy.
³ Hematology, Dipartimento Medicina Traslazionale e di Precisione, AOU Policlinico Umberto I, Sapienza University of Rome, Italy.
⁴ Department of Medical Oncology, Sapienza University of Rome, Medical and Surgical Sciences and Biotechnology, Rome, Italy.

Abstract

Background: Saprochaete capitata is a rare and emerging opportunistic fungus, involving immunocompromised hosts, in particular, neutropenic patients after chemotherapy. Case Report: We report a case of disseminated and cerebral infection by Saprochaete capitata, in a 68-year-old woman affected by acute myeloid leukemia that was successfully managed with liposomal amphotericin B and isavuconazole.

Conclusions: This case illustrates the feasibility of isavuconazole therapy in the treatment of a S. capitata infection when co-administered with midostaurin.

Keywords: Acute myeloid leukemia; CNS; Isavuconazole; Midostaurin; Saprochaete capitata.

Publication types

Case Reports