Research progress of biomarkers in early detection of chemotherapy-induced cardiotoxicity

Heart Fail Rev. 2021 Sep;26(5):1195-1201. doi: 10.1007/s10741-020-09948-6.

Abstract

With the advances of drug therapy, the prognosis of cancer patients has seen remarkable improvements, and cancer-related mortality has decreased significantly. However, the followed drug-related cardiotoxicity becomes a serious threat to patients' living quality and survival rate. Cardiovascular toxicity associated with some chemotherapy drugs is reversible and dose-dependent. If early identification is possible, early cardiovascular protection measures or adjustment of chemotherapy regimens can be taken to improve the prognosis of patients. Therefore, early prevention and monitoring of chemotherapy-related cardiotoxicity are critical for cancer patients and survivors. Among them, biomarkers are an important method for the early identification of myocardial injury.

Keywords: Biomarker; Cardiotoxicity; Chemotherapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antineoplastic Agents* / adverse effects
  • Biomarkers
  • Cardiotoxicity / diagnosis
  • Early Detection of Cancer
  • Humans
  • Neoplasms* / drug therapy

Substances

  • Antineoplastic Agents
  • Biomarkers