A H2O2-free electrochemical peptide biosensor based on Au@Pt bimetallic nanorods for highly sensitive sensing of matrix metalloproteinase 2

Xiaoxue Xi; Meiqi Wen; Shihao Song; Junlun Zhu; Wei Wen; Xiuhua Zhang; Shengfu Wang

doi:10.1039/d0cc01598a

A H₂O₂-free electrochemical peptide biosensor based on Au@Pt bimetallic nanorods for highly sensitive sensing of matrix metalloproteinase 2

Chem Commun (Camb). 2020 Jun 7;56(45):6039-6042. doi: 10.1039/d0cc01598a. Epub 2020 May 11.

Authors

Xiaoxue Xi¹, Meiqi Wen, Shihao Song, Junlun Zhu, Wei Wen, Xiuhua Zhang, Shengfu Wang

Affiliation

¹ State Key Laboratory of Biocatalysis and Enzyme Engineering & Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, People's Republic of China. wenwei@hubu.edu.cn wangsf@hubu.edu.cn.

PMID: 32391825
DOI: 10.1039/d0cc01598a

Abstract

Inspired by the excellent catalytic activity of Au@Pt bimetallic nanorods, we construct a H₂O₂-free electrochemical peptide biosensor based on Au@Pt bimetallic nanorods for highly efficient and sensitive sensing of MMP-2 for the first time, not only simplifying the traditional testing steps but also avoiding the potential damage caused by H₂O₂ to peptides and proteins.

MeSH terms

Biosensing Techniques*
Electrochemical Techniques
Gold / chemistry*
Humans
Hydrogen Peroxide
Matrix Metalloproteinase 2 / analysis*
Matrix Metalloproteinase 2 / blood
Matrix Metalloproteinase 2 / chemistry
Nanotubes / chemistry*
Peptides / chemistry*
Platinum / chemistry*

Substances

Peptides
Platinum
Gold
Hydrogen Peroxide
Matrix Metalloproteinase 2