Repetitive sequences can form a variety of alternative DNA structures (non-B DNA) that can modulate transcription, replication, and repair. However, non-B DNA-forming sequences can also stimulate mutagenesis, and are enriched at mutation hotspots in human cancer genomes. Interestingly, different types of non-B DNA stimulate mutagenesis via distinct repair processing mechanisms.
Keywords: DNA repair; DNA structure; Non-B DNA; cancer; mutagenesis.
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.