Current status of laparoscopic radical hilar cholangiocarcinoma in Mainland China

Biosci Trends. 2020 Jul 17;14(3):168-173. doi: 10.5582/bst.2020.03010. Epub 2020 May 9.

Abstract

Our purpose was to explore the status of laparoscopic radical resection of hilar cholangiocarcinoma (LRRHcca) in Mainland China. Studies published before February 2020 were retrieved from CNKI database, Pubmed database and Wanfang database. Search terms included "hilar cholangiocarcinoma", "Klatskin tumor", "laparoscopy", "radical operation". Relevant articles regarding LRRHcca in Mainland China were also retrieved. 13 articles were included in this study, with a total of 189 cases. The operation time was 354 min (weighed average, WA), and the mean intraoperative blood loss was 324 mL (WA). The rate of negative margin (R0 rate) was 95.2%, and the number of lymph nodes received was 9.5 (WA). 2.6% of cases were converted to laparotomy. The incidence of postoperative complications was 21.2%, with 3.2% for those classified as Clavien-Dindo ≥ 3, 12.2% for bile leakage, 1.6% for postoperative abdominal hemorrhage, 1.6% for liver insufficiency, and 1.1% for abdominal infection. In-hospital mortality was 0.5%, with mean postoperative hospital stay of 15 days (WA), and the rate of reoperation was 1.1%. The mean postoperative follow-up time was 16 months (WA), and 1-year overall survival rate was 84.5%. In conclusions, laparoscopic radical hilar cholangiocarcinoma is safe and feasible in experienced hands after careful selection of HCCA cases.

Keywords: Klatskin tumor; hilar cholangiocarcinoma; laparoscopy; radical operation.

Publication types

  • Review

MeSH terms

  • Anastomosis, Surgical / adverse effects
  • Anastomotic Leak / epidemiology*
  • Anastomotic Leak / etiology
  • Bile Duct Neoplasms / mortality
  • Bile Duct Neoplasms / pathology
  • Bile Duct Neoplasms / surgery*
  • Blood Loss, Surgical / statistics & numerical data
  • China / epidemiology
  • Feasibility Studies
  • Follow-Up Studies
  • Hepatic Duct, Common / pathology
  • Hepatic Duct, Common / surgery
  • Hospital Mortality
  • Humans
  • Incidence
  • Klatskin Tumor / mortality
  • Klatskin Tumor / pathology
  • Klatskin Tumor / surgery*
  • Laparoscopy / adverse effects*
  • Laparoscopy / methods
  • Length of Stay / statistics & numerical data
  • Margins of Excision
  • Postoperative Hemorrhage / epidemiology*
  • Postoperative Hemorrhage / etiology
  • Survival Rate