Recent advances in celluloses and their hybrids for stimuli-responsive drug delivery

Thennakoon M Sampath Udeni Gunathilake; Yern Chee Ching; Cheng Hock Chuah; Noorsaadah Abd Rahman; Nai-Shang Liou

doi:10.1016/j.ijbiomac.2020.05.010

Recent advances in celluloses and their hybrids for stimuli-responsive drug delivery

Int J Biol Macromol. 2020 May 7:158:670-688. doi: 10.1016/j.ijbiomac.2020.05.010. Online ahead of print.

Authors

Thennakoon M Sampath Udeni Gunathilake¹, Yern Chee Ching², Cheng Hock Chuah³, Noorsaadah Abd Rahman⁴, Nai-Shang Liou⁵

Affiliations

¹ Advanced Materials Center, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia; Department of Chemical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia.
² Advanced Materials Center, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia; Department of Chemical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: chingyc@um.edu.my.
³ Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
⁴ Department of Biochemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
⁵ Department of Mechanical Engineering, Southern Taiwan University of Science and Technology, 710 Tainan City, Taiwan, ROC.

PMID: 32389655
DOI: 10.1016/j.ijbiomac.2020.05.010

Abstract

The limitations of existing drug delivery systems (DDS) such as non-specific bio-distribution and poor selectivity have led to the exploration of a variety of carrier platforms to facilitate highly desirable and efficient drug delivery. Stimuli-responsive DDS are one of the most versatile and innovative approach to steer the compounds to the intended sites by exploiting their responsiveness to a range of various triggers. Preparation of stimuli-responsive DDS using celluloses and their derivatives offer a remarkable advantage over conventional polymer materials. In this review, we highlight on state-of-art progress in developing cellulose/cellulose hybrid stimuli-responsive DDS, which covers the preparation techniques, physicochemical properties, basic principles and, mechanisms of stimuli effect on drug release from various types of cellulose based carriers, through recent innovative investigations. Attention has been paid to endogenous stimuli (pH, temperature, redox gradient and ionic-strength) responsive DDS and exogenous stimuli (light, magnetic field and electric field) responsive DDS, where the cellulose-based materials have been extensively employed. Furthermore, the current challenges and future prospects of these DDS are also discussed at the end.

Keywords: Cellulose; Crosslinking; Drug delivery; Schiff base; Stimuli-responsive.

Publication types

Review