Interictal scalp fast ripple occurrence and high frequency oscillation slow wave coupling in epileptic spasms

Danilo Bernardo; Hiroki Nariai; Shaun A Hussain; Raman Sankar; Joyce Y Wu

doi:10.1016/j.clinph.2020.03.025

Interictal scalp fast ripple occurrence and high frequency oscillation slow wave coupling in epileptic spasms

Clin Neurophysiol. 2020 Jul;131(7):1433-1443. doi: 10.1016/j.clinph.2020.03.025. Epub 2020 Apr 10.

Authors

Danilo Bernardo¹, Hiroki Nariai², Shaun A Hussain², Raman Sankar², Joyce Y Wu²

Affiliations

¹ Department of Neurology, Division of Epilepsy, University of California, San Francisco, San Francisco, CA, USA. Electronic address: danilo.bernardo@ucsf.edu.
² Division of Pediatric Neurology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

PMID: 32387963
DOI: 10.1016/j.clinph.2020.03.025

Abstract

Objective: Intracranial high frequency oscillation (HFO) occurrence rate (OR) and slow wave activity (SWA) coupling are potential markers of epileptogenicity in epileptic spasms (ES). Scalp ripple (R) detection and SWA coupling have been described in ES; however, the feasibility of scalp fast ripple (FR) detection and measurement of scalp FR coupling to SWA is not known. We evaluated interictal scalp R and FR OR and SWA coupling in pre-treatment EEG in children with short-term treatment-refractory ES compared to short-term treatment non-refractory ES.

Methods: We retrospectively identified children with ES and identified HFOs using a semi-automated HFO detector on pre-treatment scalp EEG during sleep. We evaluated HFO OR and event-triggered modulation index (MI) to quantify R (100-250 Hz) and FR (250-600 Hz) coupling strength with different SWA passbands (0.5-1, 1-2, 2-3, 3-4, and 4-8 Hz). We used HFO phasor transform and circular statistics to evaluate phase coupling angle distributions.

Results: We identified 15 children with ES with pre-treatment EEG recorded at 2000 Hz. Thirteen out of 15 patients had HFOs and were included for analysis. There were six treatment responders and seven nonresponders three months after treatment initiation. Responders and nonresponders were similar in age (6.1 vs 7.2 mo), ES diagnosis duration (0.7 vs 2.6 mo), and HFO OR (R: 1.07 vs 2.30/min, FR: 0.43 vs 1.96/min). No differences between responders and nonresponders were seen in HFO MI at different SWA. Coupling of R and FR to 2-3 Hz SWA demonstrated increased incidence rate ratio in nonresponders relative to responders at distinct phase coupling angle distributions.

Conclusions: This study demonstrates the feasibility of interictal scalp R and FR detection and quantification of scalp R and FR coupling to SWA in ES.

Significance: HFO phase coupling with SWA may be useful as a marker of potential treatment refractoriness in patients with ES.

Keywords: Cross-frequency coupling; High frequency oscillations; Infantile spasms; Pediatric epilepsy.

MeSH terms

Child
Electroencephalography / methods*
Female
Humans
Infant
Male
Scalp
Sleep
Spasms, Infantile / diagnosis
Spasms, Infantile / physiopathology*