Subregional statistical shape modelling identifies lesser trochanter size as a possible risk factor for radiographic hip osteoarthritis, a cross-sectional analysis from the Osteoporotic Fractures in Men Study

B G Faber; T L Bredbenner; D Baird; J Gregory; F Saunders; C V Giuraniuc; R M Aspden; N E Lane; E Orwoll; J H Tobias; Osteoporotic Fractures in Men (MrOS) Study Research Group

doi:10.1016/j.joca.2020.04.011

Subregional statistical shape modelling identifies lesser trochanter size as a possible risk factor for radiographic hip osteoarthritis, a cross-sectional analysis from the Osteoporotic Fractures in Men Study

Osteoarthritis Cartilage. 2020 Aug;28(8):1071-1078. doi: 10.1016/j.joca.2020.04.011. Epub 2020 May 7.

Authors

Affiliations

¹ Medical Research Council Clinical Research Fellow, Musculoskeletal Research Unit, University of Bristol, Bristol, UK. Electronic address: ben.faber@bristol.ac.uk.
² Mechanical and Aerospace Engineering, University of Colorado Colorado Springs, Colorado, USA.
³ Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
⁴ Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK.
⁵ Center for Musculoskeletal Health, U.C. Davis School of Medicine, Sacramento, CA 95817, USA.
⁶ Bone and Mineral Unit, Oregon Health and Sciences University, Portland, OR, USA.
⁷ Musculoskeletal Research Unit, University of Bristol, Bristol, UK.

Abstract

Objective: Statistical shape modelling (SSM) of hip dual-energy X-ray absorptiometry (DXA) scans has identified relationships between hip shape and radiographic hip OA (rHOA). We aimed to further elucidate shape characteristics related to rHOA by focusing on subregions identified from whole-hip shape models.

Method: SSM was applied to hip DXAs obtained in the Osteoporotic Fractures in Men Study. Whole-hip shape modes (HSMs) associated with rHOA were combined to form a composite at-risk-shape. Subsequently, subregional HSMs (cam-type and lesser trochanter modes) were built, and associations with rHOA were examined by logistic regression. Subregional HSMs were further characterised, by examining associations with 3D-HSMs derived from concurrent hip CT scans.

Results: 4,098 participants were identified with hip DXAs and radiographs. Composite shapes from whole-hip HSMs revealed that lesser trochanter size and cam-type femoral head are related to rHOA. From sub-regional models, lesser trochanter mode (LTM)1 [OR 0.74; 95%CI 0.63.0.87] and cam-type mode (CTM)3 [OR 1.27; 1.13.1.42] were associated with rHOA, associations being similar to those for whole hip HSMs. 515 MrOS participants had hip DXAs and 3D-HSMs derived from hip CT scans. LTM1 was associated with 3D-HSMs that also represented a larger lesser trochanter [3D-HSM7 (beta (β)-0.23;-0.33,-0.14) and 3D-HSM9 (β0.36; 0.27.0.45)], and CTM3 with 3D-HSMs describing cam morphology [3D-HSM3 (β-0.16;-0.25,-0.07) and 3D-HSM6 (β 0.19; 0.10.0.28)].

Conclusion: Subregional SSM of hip DXA scans suggested larger lesser trochanter and cam morphology underlie associations between overall hip shape and rHOA. 3D hip modelling suggests our subregional SSMs represent true anatomical variations in hip shape, warranting further investigation.

Keywords: Epidemiology; Hip shape; Osteoarthritis; Statistical shape modelling.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Absorptiometry, Photon
Acetabulum / anatomy & histology
Acetabulum / diagnostic imaging*
Aged
Aged, 80 and over
Cross-Sectional Studies
Femur / anatomy & histology
Femur / diagnostic imaging*
Humans
Imaging, Three-Dimensional
Male
Middle Aged
Models, Statistical
Osteoarthritis, Hip / diagnostic imaging
Osteoarthritis, Hip / epidemiology*
Radiography
Risk Factors
Tomography, X-Ray Computed

Abstract

Publication types

MeSH terms

Grants and funding