Surgical Techniques for the Subretinal Delivery of Pediatric Gene Therapy

Kenneth C Fan; Nicolas A Yannuzzi; Nimesh A Patel; Catherin I Negron; Robert A Sisk; Aaron Nagiel; Audina M Berrocal

doi:10.1016/j.oret.2020.01.023

Surgical Techniques for the Subretinal Delivery of Pediatric Gene Therapy

Ophthalmol Retina. 2020 Jun;4(6):644-645. doi: 10.1016/j.oret.2020.01.023. Epub 2020 Feb 5.

Authors

Kenneth C Fan¹, Nicolas A Yannuzzi¹, Nimesh A Patel¹, Catherin I Negron¹, Robert A Sisk², Aaron Nagiel³, Audina M Berrocal⁴

Affiliations

¹ Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida.
² Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, Ohio; Cincinnati Eye Institute, Cincinnati, Ohio; Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
³ The Vision Center, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, California; USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California.
⁴ Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida. Electronic address: aberrocal@med.miami.edu.

Abstract

No widely accepted surgical technique for subretinal gene replacement therapy delivery in pediatric patients exists. We present alternative approaches in patients with inherited retinal diseases that aim to improve surgical success and minimize complications.

Publication types

Research Support, N.I.H., Extramural
Video-Audio Media

MeSH terms

Child
Genetic Therapy / methods*
Humans
Injections, Intraocular
Retina
Retinal Diseases / diagnosis
Retinal Diseases / therapy*
Tomography, Optical Coherence / methods
Vitrectomy / methods

Grants and funding

P30 EY014801/EY/NEI NIH HHS/United States