NLRP6 inflammasome

Runzhi Li; Shu Zhu

doi:10.1016/j.mam.2020.100859

NLRP6 inflammasome

Mol Aspects Med. 2020 Dec:76:100859. doi: 10.1016/j.mam.2020.100859. Epub 2020 May 6.

Authors

Runzhi Li¹, Shu Zhu²

Affiliations

¹ Department of Digestive Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China; Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
² Department of Digestive Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China; Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China; School of Data Science, University of Science and Technology of China, Hefei, 230026, China; CAS Centre for Excellence in Cell and Molecular Biology, University of Science and Technology of China, Hefei, China. Electronic address: zhushu@ustc.edu.cn.

PMID: 32386845
DOI: 10.1016/j.mam.2020.100859

Abstract

NOD-like receptor family pyrin domain containing 6 (NLRP6) is a novel NLR family member, that shows high expression in the intestine and liver (in contrast to NLRP3 in myeloid cells), to regulate inflammation and host defense against microbes. NLRP6 is reported to involved in inflammasome activation, regulation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling, antiviral interferon (IFN) signaling, mucus secretion, and antimicrobial peptide (AMP) production. Here, we discuss the recent findings as well as debates regarding: how NLRP6 is induced ("signal I″) and activated ("signal II"); its roles in intestinal cells and immune cells; how NLRP6 and NLRP9 coordinate to regulate the anti-viral immune response in the intestine; potential targeting of NLRP6 in human diseases.

Keywords: Anti-viral response; Goblet cell; IBD; Inflammasome; Intestinal epithelial cells; LTA; Metabolites; Microbiota; NLRP6; RNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Inflammasomes*
Inflammation
Intestines
Intracellular Signaling Peptides and Proteins
NF-kappa B* / metabolism
Signal Transduction

Substances

Inflammasomes
Intracellular Signaling Peptides and Proteins
NF-kappa B
NLRP6 protein, human