Antioxidative photochemoprotector effects of cerium oxide nanoparticles on UVB irradiated fibroblast cells

Karen E Peloi; César A Contreras Lancheros; Celso V Nakamura; Sushant Singh; Craig Neal; Tamil S Sakthivel; Sudpita Seal; Suelide Oliveira Silva Lautenschlager

doi:10.1016/j.colsurfb.2020.111013

Antioxidative photochemoprotector effects of cerium oxide nanoparticles on UVB irradiated fibroblast cells

Colloids Surf B Biointerfaces. 2020 Jul:191:111013. doi: 10.1016/j.colsurfb.2020.111013. Epub 2020 Apr 12.

Authors

Karen E Peloi¹, César A Contreras Lancheros², Celso V Nakamura¹, Sushant Singh³, Craig Neal³, Tamil S Sakthivel³, Sudpita Seal⁴, Suelide Oliveira Silva Lautenschlager⁵

Affiliations

¹ Post-Graduate Program in Pharmaceutical Sciences, State University of Maringá, Maringá, Paraná, Brazil.
² Post-Graduate Program in Microbiology, Londrina State University, Londrina, Paraná, Brazil.
³ Nanoscience Technology Center, Advanced Materials Processing and Analysis Center, Department of Materials Science and Engineering, College of Medicine, University of Central Florida, Orlando, FL, 32816, USA.
⁴ Nanoscience Technology Center, Advanced Materials Processing and Analysis Center, Department of Materials Science and Engineering, College of Medicine, University of Central Florida, Orlando, FL, 32816, USA; College of Medicine, University of Central Florida, Orlando, FL, 32816, USA.
⁵ Post-Graduate Program in Pharmaceutical Sciences, State University of Maringá, Maringá, Paraná, Brazil. Electronic address: lautenschlager@uem.br.

PMID: 32380386
DOI: 10.1016/j.colsurfb.2020.111013

Abstract

The Ultraviolet-B radiation (UVB) might induce cellular redox imbalance which plays an important role in the development of skin disorders. Thus, the search for photochemoprotective alternatives with antioxidant efficacy would be a safe aspect towards prevention of skin diseases. Cerium oxide nanoparticles (CNPs) have antioxidant properties, that are mostly related to CNPs catalase and superoxide dismutase (SOD)-like antioxidative mimetic activity. Considering that, we investigated whether CNPs induce photochemoprotection against UVB-induced cellular damages on L929 fibroblasts. Our results showed that CNPs prevented UVB mediated L929 cell oxidative damage by reestablishing the oxidative balance through ameliorating the reactive oxygen species (ROS) level and enhancing the antioxidant enzyme activities.

Keywords: Antioxidants; Cerium oxide nanoparticles; Fibroblasts; Photochemoprotection; UVB.

MeSH terms

Antioxidants / chemistry
Antioxidants / pharmacology*
Cell Survival / drug effects
Cells, Cultured
Cerium / chemistry
Cerium / pharmacology*
Fibroblasts / drug effects*
Humans
Nanoparticles / chemistry*
Particle Size
Photochemical Processes
Protective Agents / chemistry
Protective Agents / pharmacology*
Surface Properties
Ultraviolet Rays*
Wound Healing / drug effects

Substances

Antioxidants
Protective Agents
Cerium
ceric oxide