Cerebrospinal fluid folate, ascorbate, and tetrahydrobiopterin deficiency in superficial siderosis: A new potential mechanism of neurological dysfunction?

J Neurol Sci. 2020 Jul 15:414:116856. doi: 10.1016/j.jns.2020.116856. Epub 2020 Apr 19.

Authors

Jack Belsten¹, David J Werring², Howell Jones³, Simon Heales¹, Simon Pope⁴

Affiliations

¹ Neurometabolic Unit, National Hospital, Queen Square, London WC1N 3BG, United Kingdom.
² Stroke Research Centre, UCL, Queen Square, Institute of Neurology, London, United Kingdom.
³ MRC Unit of Lifelong Health and Ageing at UCL, University College London, London, United Kingdom.
⁴ Neurometabolic Unit, National Hospital, Queen Square, London WC1N 3BG, United Kingdom. Electronic address: simonpope@nhs.net.

PMID: 32380298
DOI: 10.1016/j.jns.2020.116856

No abstract available

Keywords: Antioxidant; Ascorbate; Folate; Oxidative stress; Pterin; Superficial siderosis.

Publication types

Letter

MeSH terms

Ascorbic Acid
Folic Acid
Humans
Magnetic Resonance Imaging
Phenylketonurias*
Siderosis*

Substances

Folic Acid
Ascorbic Acid