1 Translational and Clinical Research Institute, Newcastle University, Newcastle NE2 4HH, UK.
2 Translational and Clinical Research Institute, Newcastle University, Newcastle NE2 4HH, UK; National Institute for Health Research Newcastle In Vitro Diagnostics Co-operative, Newcastle University, Newcastle, UK; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK. Electronic address: j.simpson@newcastle.ac.uk.